Heterocyclic compounds for the inhibition of integrins and use thereof

US8309735B2 · kind B2 · utility

Assignee

• Shire Orphan Therapies GmbH · DE

Inventors

• Gunther Zischinsky · Berlin, DE
• Roland Stragies · Berlin, DE
• Frank Osterkamp · Berlin, DE
• Dirk Scharn · Wien, AT
• Gerd Hummel · Berlin, DE
• Holger Kalkhof · Berlin, DE
• Grit Zahn · Berlin, DE
• Doerte Vossmeyer · Berlin, DE
• Claudia Christner-Albrecht · Berlin, DE
• Ulrich Reineke · Berlin, DE

Key dates

• Filing date: May 14, 2007
• Grant date: Nov 13, 2012
• Expiry date: Apr 17, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I) wherein: A is a radical selected from the group comprising aromatic heterocyclic 5-membered ring systems; Ar is a radical selected from the group comprising optionally substituted 5- and 6-membered aromatic ring systems, whereby the ring system contains 0, 1, 2 or 3 heteroatoms selected from the group comprising N, O and S; Z is a linker and Ψ is a radical of formula (II) and their use for the inhibition of integrin.