FTY720-derived anticancer agents
US8309768B2 · kind B2 · utility
5Cited by
12References
16Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 29, 2011 |
| Grant date | Nov 13, 2012 |
| Priority date | — |
| Expiry date | Nov 29, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A number of FTY720-derived compounds with antitumor activity are described. These compounds include the compounds of formula I:wherein R1 is independently selected from the group consisting of hydrogen, methyl. methoxy, and hydroxyl; R2 is independently selected from the group consisting of hydrogen, methoxy, and hydroxyl; R3 is independently selected from the group consisting of alkyl and cyclo-alkyl; and n is independently selected from 0 to 6. The compounds have lower immunosuppressive side effects as a result of not being phosphorylated by sphingosine kinase 2.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.