Human monoclonal antibodies against hendra and nipah viruses

US8313746B2 · kind B2 · utility

Assignees

• The Henry Jackson Foundation for the Advancement of Military Medicine, Inc. · US
• The United States of America as Represented by The Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer · US

Inventors

• Dimiter S. Dimitrov · Frederick, US
• Zhongyu Zhu · Frederick, US
• Christopher C. Broder · Silver Spring, US

Key dates

• Filing date: Aug 1, 2011
• Grant date: Nov 20, 2012
• Expiry date: Aug 1, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2469/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.