Compositions for targeted delivery of siRNA
US8313772B2 · kind B2 · utility
63Cited by
17References
25Claims
0Family size
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Key dates
| Filing date | Feb 22, 2011 |
| Grant date | Nov 20, 2012 |
| Priority date | — |
| Expiry date | Feb 22, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.