Patent · US Active

Methods for expressing ADAMTS proteins in cell culture medium supplemented with zinc

US8313926B2 · kind B2 · utility

22Cited by

0References

30Claims

0Family size

Assignees

Baxter International Inc. · US
Baxter Healthcare SA · CH

Inventors

Leopold Grillberger · Wien, AT
Alexandra Spenger · Wien, AT
Meinhard Hasslacher · Wien, AT
Rana Grillberger · Wien, AT
Manfred Reiter · Wien, AT

Key dates

Filing date	Jul 30, 2010
Grant date	Nov 20, 2012
Priority date	—
Expiry date	Jul 30, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2510/02
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides culture mediums that are useful for the expression of ADAMTS proteins, such as ADAMTS13. Methods for the expression and purification of ADAMTS proteins are also provided. In some embodiments, the mediums and methods of the invention are useful for the expression of ADAMTS proteins having high specific activities. Also provided are ADAMTS, e.g., ADAMTS13, protein compositions with high specific activities, which are expressed and purified according to the methods provided herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.