Pyridyl derivatives, their preparation and use

US8314103B2 · kind B2 · utility

Assignee

• PIRAMAL ENTERPRISES LIMITED · IN

Inventors

• Sanjay Kumar · Moraga, US
• Kalpana Joshi · Jamkhed, IN
• Vijaykumar Deore · Mumbai, IN
• Mandar Ramesh Bhonde · Pune, IN
• Nilambari Nilkanth Yewalkar · Pune, IN
• Amol Arun Padgaonkar · Mumbai, IN
• Asha Kulkarni-Almeida · Mumbai, IN
• Maggie Joyce Rathos · Mumbai, IN
• Sapna Parikh · Mumbai, IN
• Nilesh Madhukar Dagia · Mumbai, IN

Key dates

• Filing date: Aug 6, 2008
• Grant date: Nov 20, 2012
• Expiry date: Sep 14, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3k), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor 1α (HIF-1α) mediated signaling. Also disclosed are processes for preparation of the pyridyl derivatives, and their use in the manufacture of pharmaceutical compositions for the treatment of clinical conditions caused by deregulation of signaling pathways selected from one or more of PI3K, mTOR and HIF-1α pathways. The pyridyl derivatives are also useful for the treatment of conditions or disorders mediated by TNF-α.