5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone and the intermediates for production thereof
US8314132B2 · kind B2 · utility
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Key dates
| Filing date | Jun 18, 2008 |
| Grant date | Nov 20, 2012 |
| Priority date | — |
| Expiry date | Jun 18, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D285/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Invention is related to novel compounds -5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles with general formula (I). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit Hsp90 chaperone which participate in cancer progression. This invention is also related to new intermediate compounds which are used for the synthesis of thiadiazoles of general formula (I).
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