Patent · US Active

Process for the preparation of an enantiomeric trisubstituted 3,4-dihydro-isoquinoline derivative

US8314238B2 · kind B2 · utility

0Cited by

0References

12Claims

0Family size

Assignee

Actelion Pharmaceuticals Ltd. · CH

Inventors

Erhard Bappert · Parma, IT
Andreas Hendrikus Maria De Vries · Echt, NL
Doris Domin · Wien, AT
Matthias Helms · Linz, AT
Christoph Imboden · Solothurn, CH
Zarghun Nazir · Linz, AT
Wolfgang Skranc · Wien, AT
Felix Spindler · Starrkirch-Wil, CH
Michael Stanek · San Clemente, US
Wilhelm Tschebull · Linz, AT
Gerardus Karel Maria Verzijl · Venray, NL

Key dates

Filing date	Dec 23, 2008
Grant date	Nov 20, 2012
Priority date	—
Expiry date	Jul 1, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D217/02
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.