Attenuated bacteria useful in vaccines
US8318148B2 · kind B2 · utility
0Cited by
5References
48Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 28, 2011 |
| Grant date | Nov 27, 2012 |
| Priority date | — |
| Expiry date | Mar 28, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides strains of bacteria, especially enterotoxigenic E. coli, attenuated by mutations in the genes encoding enterotoxins (LT, ST, EAST1) and optionally further attenuated by deletion of additional chromosomal genes. In addition the invention provides strains of attenuated bacteria expressing immunogenic but non-toxic variants of one or more of these enterotoxins. These bacteria are useful as a vaccine against diarrhoeal disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.