Replication competent viruses capable of silencing virus inhibitory factor expression

US8318149B2 · kind B2 · utility

Assignee

• VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG · NL

Inventors

• Jan E. Carette · Palo Alto, US
• Victor Willem Van Beusechem · Amstelveen, NL

Key dates

• Filing date: Oct 9, 2006
• Grant date: Nov 27, 2012
• Expiry date: Jan 6, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/85
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described is a replication-competent virus capable of replication and having lytic capacity in target cells. The virus comprises in the genome thereof, at least one DNA sequence coding for a silencing factor functional in reducing expression of a target gene in the target cells, operably linked to one or more expression control sequences, functional in the target cells. The use thereof in the preparation of a medicament and the use thereof in a method for lysing target cells expressing a virus inhibitory factor are also described.