Antibodies against human melanoma-associated chondroitin sulphate proteoglycan (MCSP)
US8318165B2 · kind B2 · utility
2Cited by
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Key dates
| Filing date | Sep 10, 2007 |
| Grant date | Nov 27, 2012 |
| Priority date | — |
| Expiry date | Oct 20, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/90
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides isolated antibodies (e.g., humanized or human antibodies) that bind to the membrane-proximal domain (MP) of human Melanoma-Associated Chondroitin Sulphate Proteoglycan (MCSP), and are capable of mediating cytolysis of a cell expressing MCSP in the presence of human effector cells or complement. Methods of using such antibodies to induce cytolysis (e.g., ADCC or CDCC) of cells expressing MP-MCSP are also provided.
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