Method of regulating glucose metabolism, and reagents related thereto
US8318669B2 · kind B2 · utility
2Cited by
17References
27Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Nov 9, 2010 |
| Grant date | Nov 27, 2012 |
| Priority date | — |
| Expiry date | Nov 9, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods for modification and regulation of glucagon-like peptide 1 (GLP-1) metabolism by administering therapeutically effective amounts of an inhibitor of dipeptidylpeptidase IV (DPIV) or a pharmaceutically acceptable salt thereof, where the inhibitor has a Ki for inhibition of DPIV of 10 nM or less; and the inhibitor is administered in an amount sufficient to inhibit DPIV proteolysis of GLP-1 but not sufficient to suppress the immune system of the animal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.