Nitroso compounds as nitroxyl donors and methods of use thereof
US8318705B2 · kind B2 · utility
21Cited by
3References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 7, 2009 |
| Grant date | Nov 27, 2012 |
| Priority date | — |
| Expiry date | Dec 18, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.