Pyrrolopyrimidines

US8318731B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Gaston Stanislas Marcella Diels · Ravels, BE
• Peter Ten Holte · Beerse, BE
• Eddy Jean Edgard Freyne · Rumst, BE
• Thierry Andre Regis Grand-Perret · Brussels, BE
• Kristof Van Emelen · Sint-Niklaas, BE
• Werner Constant Johan Embrechts · Beerse, BE
• Pascal Ghislain André Bonnet · Berchem, BE

Key dates

• Filing date: Jul 25, 2008
• Grant date: Nov 27, 2012
• Expiry date: Mar 9, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds or pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to compounds that are polo-like kinase (PLKs) inhibitors useful for the treatment of disease states mediated by PLK, especially PLK4, in particular such compounds that are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumor growth, rheumatoid arthritis, restenosis and atherosclerosis.