Polymorphic forms of 1-′4-(5-cyanoindol-3-yl) butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride

US8318744B2 · kind B2 · utility

Assignee

• Merck Patentgesellschaft · DE

Inventors

• Andreas Bathe · Darmstadt, DE
• Bernd Helfert · Ober-Ramstadt, DE
• Steffen Neuenfeld · Messel, DE
• Heike Kniel · Heppenheim, DE
• Matthias Bartels · Darmstadt, DE
• Susanne Rudolph · Dieburg, DE
• Henning Bottcher · Darmstadt, DE

Key dates

• Filing date: Apr 12, 2011
• Grant date: Nov 27, 2012
• Expiry date: Apr 12, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.