Compounds involving mGluR5 receptor regulation and methods of making the compounds

US8318774B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Michael Haurand · Aachen, DE
• Klaus Schiene · Goldkronach, DE
• Sven Kühnert · St. Blasien, DE
• Melanie Reich · Aachen, DE

Key dates

• Filing date: Jun 26, 2008
• Grant date: Nov 27, 2012
• Expiry date: Feb 17, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

3-((Thiazol-2-yl)amino)propylproiolamide compounds of the formula I:wherein the variables are as defined herein, are useful to prevent or treat a disease or disorder involving mGluR5 receptor regulation. Also disclosed are pharmaceutical compositions containing the compounds and methods of making the compounds.