Therapeutic nucleic acid-3′-conjugates
US8318920B2 · kind B2 · utility
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Key dates
| Filing date | Apr 13, 2007 |
| Grant date | Nov 27, 2012 |
| Priority date | — |
| Expiry date | May 28, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are described for improvement of the serum half life of therapeutic nucleic acids by 3′ conjugation to useful target proteins, or other large molecules with useful function. In one embodiment, a 3′ A, C or G overhang is added to ds-DNA and the primary amines conjugated using biocompatible bifunctional linkers to proteins. The resulting nucleic acid-3′-conjugates are serum nuclease-resistant and retained in vivo for long periods without rapid kidney clearance. Further, the choice of conjugate imparts additional functionality to the nucleic acid-3-conjugate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.