Preparation of opiate analgesics by reductive alkylation
US8318937B2 · kind B2 · utility
3Cited by
7References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 18, 2011 |
| Grant date | Nov 27, 2012 |
| Priority date | — |
| Expiry date | Feb 18, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing a compound of formula (A), (B) or (C):wherein P is H, CH3 or a hydroxyl protecting group; X is O, a protected ketone, OH, a protected hydroxyl group or H; Y is OH, a protected hydroxyl group or H; W is C(CH3)2OH, C(CH3)(C(CH3)3)OH or COCH3; Z is C2-C10 alkyl or C2-C10 arylalkyl; and is a single bond or a double bond, is disclosed. The process is a reductive alkylation in the presence of hydrogen and a reductive alkylation catalyst.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.