Mouse models with enhanced essential tremor and preparation method thereof
US8319007B2 · kind B2 · utility
0Cited by
0References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 7, 2010 |
| Grant date | Nov 27, 2012 |
| Priority date | — |
| Expiry date | Sep 17, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0306
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein are an α1/CaV3.1 double knockout mouse or α1−/−; Emx1-Cre mouse with enhanced essential tremor and a screening method of therapeutic agents for essential tremor by using the same. The α1/CaV3.1 double knockout mouse or α1−/−; Emx1-Cre mouse of the present invention may be usefully used for development of therapeutic agents for essential tremor because the mouse exhibits essential tremor strong and evident enough to be visually confirmed, compared to an α1 knockout mouse.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.