Powder formation by atmospheric spray-freeze drying
US8322046B2 · kind B2 · utility
39Cited by
205References
15Claims
0Family size
Inventors
Key dates
| Filing date | Mar 18, 2008 |
| Grant date | Dec 4, 2012 |
| Priority date | — |
| Expiry date | Aug 31, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/25
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.