Ricin A chain mutants lacking enzymatic activity as vaccines to protect against aerosolized ricin
US8323665B2 · kind B2 · utility
0Cited by
9References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 12, 2007 |
| Grant date | Dec 4, 2012 |
| Priority date | — |
| Expiry date | Jul 6, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/168
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods to produce toxoid vaccines, such as ricin A chain vaccines, with reduced ability to promote vascular leak syndrome (VLS) and catalytic toxicity associated with various proteinaceous toxins, such as ribosome inactivating proteins. The invention also provides toxoids which have been mutated to lack amino acid sequences which induce VLS and toxic catalytic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.