Methods of identifying small molecules for renewals, survival and migration of cardiac progenitors
US8323909B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Apr 29, 2010 |
| Grant date | Dec 4, 2012 |
| Priority date | — |
| Expiry date | Oct 18, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3β inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.