Chloroacetamidine based inhibitors and activity based probes for the protein arginine methytransferases

US8323918B2 · kind B2 · utility

Assignee

• UNIVERSITY OF SOUTH CAROLINA · US

Inventors

• Paul R. Thompson · Columbia, US
• Tanesha C. Osborne · Augusta, US
• Obiamaka Obianyo · Columbia, US
• Corey P. Causey · Jacksonville, US

Key dates

• Filing date: Dec 14, 2009
• Grant date: Dec 4, 2012
• Expiry date: Sep 23, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In accordance with certain embodiments of the present disclosure, a protein arginine methyltransferase inhibitor is provided. The inhibitor comprises an amino acid peptide joined to a chloroacetamidine warhead.