Patent · US Active

Differentiation of pluripotent cells into primary germ layer progenitors

US8323971B2 · kind B2 · utility

8Cited by

2References

17Claims

0Family size

Assignee

Cambridge Enterprise Limited · GB

Inventors

Roger Pedersen · Cambridge, GB
Ludovic Vallier · Cambridge, GB

Key dates

Filing date	Nov 9, 2007
Grant date	Dec 4, 2012
Priority date	—
Expiry date	Mar 18, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2533/52
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

This invention relates to the culture of pluripotent cells in a fully humanised chemically defined medium. Cells may be cultured over a prolonged period of time without losing their pluripotent status or may be controllably induced to differentiate into progenitor cells of the three primary germ layers by the addition of differentiation factors, for example differentiation factors which modulate one or more of the Activin/Nodal, FGF, Wnt or BMP signalling pathways.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.