Telomere-encoding synthetic DNA nanocircles, and their use for the elongation of telomere repeats
US8323975B2 · kind B2 · utility
4Cited by
8References
18Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 26, 2009 |
| Grant date | Dec 4, 2012 |
| Priority date | — |
| Expiry date | Oct 3, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Telomere-encoding nucleic acid nanocircles, methods for their preparation, and methods for their use are disclosed. The nanocircles can be constructed containing multiple repeats of the complement of telomere repeat sequences. The telomere-encoding nanocircles are useful for extending telomeres both in vitro and in vivo, for treating macular degeneration, the effects of skin aging, liver degeneration, and cancer. The nanocircles are further useful for treating cell cultures to produce long-lived non-cancerous cell populations. This use has wide applicability in scientific research, tissue engineering, and transplantation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.