Substituted piperazines
US8324216B2 · kind B2 · utility
4Cited by
52References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 8, 2009 |
| Grant date | Dec 4, 2012 |
| Priority date | — |
| Expiry date | Nov 6, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.