Dendritic cell vaccine compositions and uses of same
US8324369B2 · kind B2 · utility
11Cited by
21References
14Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 26, 2008 |
| Grant date | Dec 4, 2012 |
| Priority date | — |
| Expiry date | Jan 7, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides adjuvants, vaccines and therapies in which antigen presentation is enhanced through inhibition of negative immune regulators. The compositions and methods are useful for generating immune responses against antigens, including microbial pathogens and tumor-associated antigens, by way of inhibiting a negative immune regulator in a cell and providing a proinflammatory stimulus. In particular, nucleotides encoding inhibitors of negative immune regulators, antigens, and co-stimulatory molecules are contacted with immune cells in order to elicit a therapeutic or prophylactic response.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.