Diacylglycerol acyltransferase inhibitors

US8324385B2 · kind B2 · utility

Assignee

• Madrigal Pharmaceuticals, Inc. · US

Inventors

• David Robert Bolin · Montclair, US
• Adrian Wai-Hing Cheung · Glen Rock, US
• Matthew Hamilton · Hackettstown, US
• Nicholas Marcopulos · North Caldwell, US
• Lee Apostle McDermott · Sayreville, US
• Yimin Qian · Plainsboro, US

Key dates

• Filing date: Oct 20, 2009
• Grant date: Dec 4, 2012
• Expiry date: Jun 6, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided herein are compounds of the formula (I):were RI is phenyl, R2 is hydrogen, halogen or lower alkyl, X is carbon on nitrogen, and R3 is isoquinoline, -amino, or a -4- to 6-membered heterocycloalkyl ring and pharmaceutically acceptable salts thereof, which are active as DGAT inhibitors and therefore find uses in treatment of diseases associated with abnormal metabolism of trigliceride. such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.