MEMS interstitial prothrombin time test
US8328720B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 11, 2008 |
| Grant date | Dec 11, 2012 |
| Priority date | — |
| Expiry date | Jul 13, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/02035
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method of determining a prothrombin time is disclosed. A mediator is applied to a stratum corneum. The stratum corneum is penetrated to allow the mediator to enter a region containing interstitial fluid and interact with at least one capillary, causing blood and/or blood components to leak from the at least one capillary into the region containing interstitial fluid. A characteristic affected by the blood and/or blood components is measured in the region containing interstitial fluid which correlates to the prothrombin time. A system for measuring prothrombin time is also disclosed. The system has a mediator, one or more microneedles, and a processor directly or indirectly coupled to the one or more microneedles and configured to determine a coagulation change in blood or blood components in a region around the one or more microneedles after the one or more microneedles penetrate a stratum corneum.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.