Quaternary ammonium functionalized glycodendrimers, methods for the production and use thereof
US8329155B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 12, 2007 |
| Grant date | Dec 11, 2012 |
| Priority date | — |
| Expiry date | Aug 27, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel antimicrobial agents that are quaternary ammonium functionalized glycodendrimers. In one embodiment, the quaternary ammonium functionalized glycodendrimers are compounds of Formula (I): (Q+−-S-L)z-DnX− wherein: D is a dendrimer; n is the generation number of the functionalized dendrimer; z is an integer less than or equal to 2(n+2); L is a linking group; Q+ represents a quaternary ammonium moiety; and S represents a carbohydrate moiety. The present invention further provides formulations containing the antimicrobial agents of the invention, methods of making the agents and formulations of the invention, and methods of using the same as effective and/or broad spectrum antimicrobial agents. The agents and formulations of the invention find use in medicine, for the treatment of various inflammatory conditions or diseases, for example, and have numerous industrial applications.(Q+−-S-L)z-DnX− (I)
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.