Methods for producing ECM-based biomaterials
US8329219B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 22, 2009 |
| Grant date | Dec 11, 2012 |
| Priority date | — |
| Expiry date | Aug 7, 2030 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB29C67/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for forming an extracellular matrix material (ECM) material includes providing at least an ECM composition containing ECM particles varying in their capacity for migration through a fluid medium, including at least one population of expanded ECM particles. The ECM composition is combined in a fluid medium to form a flowable ECM composition. The flowable ECM composition is subjected to a centrifugal force in a mold for a period of time sufficient to distribute the ECM particles according to differences in their physical characteristics. The ECM composition is dried to form a dried ECM material having a density gradient extending from a less dense region to a more dense region. The dried ECM material may formed as a porous, substantially acellular ECM material expandable in an aqueous fluid environment by at least 100% in volume.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.