Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients
US8329221B2 · kind B2 · utility
2Cited by
8References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 2, 2010 |
| Grant date | Dec 11, 2012 |
| Priority date | — |
| Expiry date | Dec 1, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1652
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Coprocessed compositions containing calcium phosphate and microcrystalline cellulose are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. Such compositions may be obtained by preparing aqueous slurries of microcrystalline cellulose and calcium phosphate and drying such slurries to produce particulate products. The coprocessed products exhibit improved compactibility, as compared to dry physical blends of the same components.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.