Monoclonal antibody and use thereof
US8329414B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 11, 2011 |
| Grant date | Dec 11, 2012 |
| Priority date | — |
| Expiry date | May 11, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The purpose of the invention is to provide an antibody which recognizes OPN N-half but does not recognize the full-length OPN, and its use. A monoclonal antibody which is characterized in that it recognizes a protein or polypeptide in which the C-terminal amino acid sequence is YGLR (SEQ ID NO: 1) and it substantially does not recognize a protein or polypeptide which has an amino acid sequence of YGLR outside of the C-terminal, as well as a method for measuring OPN N-half utilizing the said antibody, a method for diagnosing diseases relating to OPN N-half, a method for judging the severity of said disease, and a method for treating said diseases, are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.