Methods for increasing vascularization

US8329655B2 · kind B2 · utility

Assignees

• BIOGEN IDEC MA INC. · US
• INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) · FR

Inventors

• Anthony Rossomando · Grafton, US
• Jean-Sebastien Silvestre · Paris, FR
• Radia Tamarat · Paris, FR

Key dates

• Filing date: May 1, 2008
• Grant date: Dec 11, 2012
• Expiry date: Jun 9, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/475
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject.