Antisense antiviral compound and method for treating picornavirus infection
US8329668B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 8, 2006 |
| Grant date | Dec 11, 2012 |
| Priority date | — |
| Expiry date | Sep 8, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/32711
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Enterovirus and/or Rhinovirus infection in a mammal. The antisense antiviral compounds are substantially uncharged, including partially positively charged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 5′ untranslated region identified by SEQ ID NO:4.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.