Pyrrolo-nitrogenous heterocyclic derivatives, the preparation and the pharmaceutical use thereof

US8329682B2 · kind B2 · utility

Assignee

• SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. · CN

Inventors

• Peng Cho Tang · Moraga, US
• Yidong Su · 安丰镇, CN
• Yali Li · Cambridge, GB
• Lei Zhang · Beijing, CN
• Fuqiang Zhao · Chengdu, CN
• Jialiang Yang · Hangzhou City, CN
• Ying Zhou · Shanghai, CN
• Pingyan Bie · Shanghai, CN
• Guangtao Qian · Shanghai, CN
• Minggang Ju · Shanghai, CN

Key dates

• Filing date: May 14, 2008
• Grant date: Dec 11, 2012
• Expiry date: Feb 5, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides new pyrrolo-nitrogenous heterocyclic derivatives represented by formula (I) or their salts, the preparation thereof, pharmaceutical compositions containing such derivatives and the use of such derivatives as therapeutic agents, especially as protein kinase inhibitors, wherein each substituent in formula (I) is same as defined in the description.