Pyrazine compounds as phosphodiesterase 10 inhibitors

US8329700B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Jennifer R. Allen · Newbury Park, US
• Matthew P. Bourbeau · Calabasas, US
• Ning Chen · Thousand Oaks, US
• Essa Hu · Camarillo, US
• Roxanne Kunz · Santa Monica, US
• Shannon Rumfelt · Camarillo, US

Key dates

• Filing date: Mar 7, 2011
• Grant date: Dec 11, 2012
• Expiry date: Mar 7, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyrazine compounds of formula (I):or a pharmaceutically acceptable salt thereof, wherein m, n, p, R1, R2, R3, R4, X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, Y and Z are defined in the specification, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.