Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof
US8329870B2 · kind B2 · utility
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29Claims
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Key dates
| Filing date | Jan 6, 2008 |
| Grant date | Dec 11, 2012 |
| Priority date | — |
| Expiry date | Jun 7, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides water-soluble reactive esters of carboxy polysaccharides and derivatives thereof. The reactive carboxy polysaccharide derivatives are useful per se in aqueous solutions or specifically for the formation of water-soluble covalent fibrinogen conjugates. A preferred conjugate is a hyaluronic acid-fibrinogen conjugate and fibrin adhesive, clot or matrix derived from it. Methods of preparation and methods of use in tissue repair and regeneration are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.