Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith
US8329876B2 · kind B2 · utility
6Cited by
18References
17Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 26, 2011 |
| Grant date | Dec 11, 2012 |
| Priority date | — |
| Expiry date | Oct 26, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the α-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.