Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranoses

US8329925B2 · kind B2 · utility

Assignee

• LIBRAMEDICINA, Inc. · JP

Inventors

• David Voigtländer · West Lafayette, US
• Michael Sander · Blankenloch, DE
• Michael Harre · Berlin, DE

Key dates

• Filing date: Dec 3, 2010
• Grant date: Dec 11, 2012
• Expiry date: Jun 30, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H13/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for preparing 1-O-acyl-2-deoxy-2-fluoro-4-thio-β-D-arabinofuranoses having formula I and intermediates thereof:wherein R1 represents —C(O)—C1-C6-alkyl or —C(O)-aryl; and R2 represents C1-C6-alkyl, C1-C4-perfluoroalkyl or aryl.