Process for preparation of trans 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1Napthalenamine

US8329950B2 · kind B2 · utility

Assignee

• Sunovion Pharmaceuticals Inc. · US

Inventors

• Judy Caron · Westwood, US
• Thomas Wessel · Frankfurt, DE
• Karim Lalji · Aliso Viejo, US
• Mark A. Varney · Laguna Niguel, US
• Roger P. Bakale · Summit, US
• Surendra Singh · Shrewsbury, US
• H. Scott Wilkinson · Westborough, US
• Xiping Su · Woodbridge, US
• Zhengxu Han · Shrewsbury, US
• Stefan G. Koenig · Shrewsbury, US

Key dates

• Filing date: Jan 25, 2012
• Grant date: Dec 11, 2012
• Expiry date: Jan 25, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.