Patent · US Active

HSA-free formulations of interferon-Beta

US8333958B2 · kind B2 · utility

0Cited by

18References

43Claims

0Family size

Assignee

Novartis Vaccines and Diagnostics, Inc. · US

Inventors

Bret A. Shirley · Concord, US
Susan Babuka · Oakland, US
Bao-Lu Chen · San Ramon, US
Maninder Hora · Danville, US
Minna Choe · Danville, US
Melanie Tellers · Cranford, US

Key dates

Filing date	Jan 11, 2011
Grant date	Dec 18, 2012
Priority date	—
Expiry date	Jan 11, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P37/02
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β solubilized in a low-ionic-strength formulation that maintains the composition at a pH of about 3.0 to about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-β in pharmaceutical compositions, are provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.