Non-glycerol stabilized bone graft

US8333985B2 · kind B2 · utility

Assignee

• Warsaw Orthopedic, Inc.

Inventors

• David Knaack · Summit, US
• Michele Diegmann · Scotch Plains, US
• Albert Manrique · Manalapan, US
• Keyvan Benham · Red Bank, US

Key dates

• Filing date: Jan 27, 2005
• Grant date: Dec 18, 2012
• Expiry date: Feb 11, 2029

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B33Y80/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A demineralized bone matrix (DBM) or other matrix composition is provided that has been stabilized by lowering the pH of the composition, reducing the water content, adding water substitutes, and/or increasing the amount of deuterated water present in the composition in order to reduce the activity of endogenous degrading enzymes such as proteases. A hydrated form of a stabilized DBM composition may be stable up to a year at room temperature at acidic pH. The acidified DBM compositions may be further stabilized by the addition of a stabilizing agent such as deuterated water, water substitutes, polymers, protease inhibitors, glycerol or hydrogels.