Protein microspheres having injectable properties at high concentrations
US8333995B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 12, 2005 |
| Grant date | Dec 18, 2012 |
| Priority date | — |
| Expiry date | May 12, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical that are substantially amorphous or non-crystalline and are injectable through fine gauge needles at high concentrations. The invention has special application for higher molecular weight proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.