Methods for nucleic acid transfer into cells
US8334272B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Oct 12, 2010 |
| Grant date | Dec 18, 2012 |
| Priority date | — |
| Expiry date | Oct 12, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods for increasing the transfer of nucleic acids into cells. In particular, the present invention provides for the use of inhibitors of HDAC6, a cytoplasmic histone deacetylase present in mammalian cells by, for example, small molecules or siRNA treatment, in increasing gene transfer and/or expression in cells in vitro and in vivo for research and gene therapy applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.