Process for the production of artemisinin intermediates

US8334392B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Volker Kraft · Frankfurt am Main, DE
• Gerhard Kretzschmar · Eschborn, DE
• Kai Rossen · Hanau, DE

Key dates

• Filing date: Sep 10, 2010
• Grant date: Dec 18, 2012
• Expiry date: Jun 25, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This application relates to a process for the production of (2R)-dihydroartemisinic acid or (2R)-dihydroartemisinic acid esters from artemisinic acid or artemisinic acid esters, respectively, by diimine hydrogenation of the exocyclic CC-double bond, and use of said process in the production of the antimalarial drug artemisinin.