Chiral thiourea compounds and process for enantioselective reduction of ketones
US8334405B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Apr 3, 2008 |
| Grant date | Dec 18, 2012 |
| Priority date | — |
| Expiry date | Jan 24, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Chiral thioureas are effective catalysts for the borane reduction of prochiral ketones to optically active alcohols. A prochiral ketone may be reduced to an optically active alcohol in the presence of a substantially sub-stoichiometric amount of chiral thiourea. The asymmetric thiourea compound of the present invention may be produced according to a production method described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.