Mathematical design of ion channel selectivity via inverse problem technology
US8335671B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Apr 11, 2007 |
| Grant date | Dec 18, 2012 |
| Priority date | — |
| Expiry date | May 6, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B15/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
Determining the structure of permanent charge for an ion channel formulates an abstract operator, describing ion channel parameters, comprising equations that are ill-posed. The model of ion channel behavior relates the function of the ion channel to the structure of permanent charge within the ion channel and concentrations ions around the ion channel under certain properties and boundary conditions. The model also includes regularization of the abstract operator by approximating the ill-posed equations with a family of well-posed equations. An estimate of the closeness of the well-posed solution to the ill-posed solution is provided. Providing stable and convergent algorithms allows the model to determine a stability for the regularized solution, so that a regularization parameter can determine a balance between the stability and accuracy of the solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.