Preparation of compositions with essentially noncrystalline embedded macrolide antibiotics

US8337733B2 · kind B2 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Ulrich Westedt · Schriesheim, DE
• Jörg Rosenberg · Ellerstadt, DE
• Martin Knobloch · Schifferstadt, DE
• Norbert Steiger · Lingenfeld, DE
• Harald Hach · Bad Bergzabern, DE

Key dates

• Filing date: Aug 14, 2008
• Grant date: Dec 25, 2012
• Expiry date: Sep 28, 2028

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B29C48/67
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A description is given of a process for the preparation of a pharmaceutical composition of a macrolide antibiotic in essentially noncrystalline form, in which the macrolide antibiotic, a water-swellable polymer and a proton donor are blended in an extruder in the presence of water and forced through a die, the ratio by weight of the sum of macrolide antibiotic, water-swellable polymer and proton donor to water being at least 1:1. The macrolide antibiotic is preferably clarithromycin and the water-swellable polymer is preferably chosen from crosslinked polyvinylpyrrolidone, crosslinked sodium carboxymethylcellulose and crosslinked polyacrylic acid.