Operator independent programmable sample preparation and analysis system
US8337755B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 13, 2006 |
| Grant date | Dec 25, 2012 |
| Priority date | — |
| Expiry date | Jan 10, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/113332
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a protocol and apparatus for enriching circulating tumor cells and other rare cells from blood, including debris and other components, from samples with high precision and at high throughput rates. This invention discloses an improved processing system from previously described semi-automated sample processing. The system further reduces operator intervention and hands-on time from prior systems. While this system has general utility in processing diverse materials, the system is configured for sample processing of biological specimens to provide an enriched fraction suitable for detection, enumeration and identification of target cells by appropriate analytical methodologies. The presence and quantities of such target cells in a sample specimen can utilized for screening and detection in disease such as cancer, assessing early stage pre-metastatic cancer, monitoring for disease remission in response to therapy and selection of more effective dose regimens or alternative therapies in case of relapse.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.